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MouseAccession
P01137, P61812, P10600克隆号
1D11.16.8抗体类型
Mouse mAb抗体同种型
IgG1,k同型对照
Invivo mouse IgG1 isotype control应用
In vivo TGF-β neutralization, In vitro TGF-β neutralization反应种属 ?
Bv, Mk, Dg, Hm, Hu, Ms, Rt纯化方式
Protein G浓度
5 mg/ml纯度
≥95%内毒素含量
<2EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, containing no preservative
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
This antibody recognizes the same epitope as clone 1D11.16.8. TGF beta, or Transforming Growth Factor Beta, is a multifunctional protein that plays crucial roles in various physiological processes such as cell growth, differentiation, apoptosis, tissue repair, and immune response. TGF beta stimulates the proliferation and differentiation of various cell types, including fibroblasts, epithelial cells, and endothelial cells. It accomplishes this by activating intracellular signaling pathways that regulate cell cycle progression and differentiation directions. Following injury or tissue damage, the expression of TGF beta significantly increases, participating in the tissue repair and regeneration process. It promotes cell migration, proliferation, and the synthesis of extracellular matrix components, thereby accelerating wound healing. TGF beta can also be involved in tumorigenesis and development in certain circumstances. Abnormal activation of the TGF beta signaling pathway can promote excessive cell proliferation and transformation, contributing to tumor formation and progression.
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