Anti-HER2 Monoclonal Antibody(Pertuzumab)
Receptor tyrosine-protein kinase erbB-2,Metastatic lymph node gene 19 protein (MLN 19),Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2,CD340,ERBB2,MLN19,NEU,NGL
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宿主来源
Human分子别名
Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein (MLN 19), Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340, ERBB2, MLN19, NEU, NGLAccession
P04626克隆号
S-SC018抗体类型
Recombinant mAb抗体同种型
IgG1,k纯化方式
Protein A浓度
2 mg/ml内毒素含量
<1EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, containing no preservative
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
Blocking of HER2 signaling Functional assays
稀释度
应用 稀释度 ELISA 1.221-5000 ng/ml
Pertuzumab is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it also used in the same combination as a neoadjuvant in early HER2-positive breast cancer. It is the first-in-class of a kind of drug called a "HER dimerization inhibitor" — it inhibits the dimerization of HER2 with other HER receptors, which prevents them from signalling in ways that promote cell growth and proliferation.
ELISA
Immobilized Her2 His Tag Protein, Human(UA010176) can bind Pertuzumab. The EC50 for this effect is 40.85 ng/mL.
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