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宿主来源
Human抗原名称
FGFR2分子别名
Fibroblast growth factor receptor 2, CD332, KGFR, Keratinocyte growth factor receptor, K-samAccession
P21802克隆号
BAY 1179470抗体类型
Recombinant mAb抗体同种型
IgG1,λ纯化方式
Protein A浓度
2 mg/ml内毒素含量
<1EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, containing no preservative储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
Blocking of FGFR2 signaling Functional assays稀释度
应用 稀释度 ELISA 0.3-2000 ng/ml
Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10.[5][6] FGFR2 is a receptor for fibroblast growth factor. FGFR2 has important roles in embryonic development and tissue repair, especially bone and blood vessels. Like the other members of the fibroblast growth factor receptor family, these receptors signal by binding to their ligand and dimerisation (pairing of receptors), which causes the tyrosine kinase domains to initiate a cascade of intracellular signals. On a molecular level these signals mediate cell division, growth and differentiation. Recombinant Human monoclonal antibody expressed in HEK293 binding to Human FGFR2. This is a novel fibroblast growth factor receptor 2 (FGFR2) directed antibody used for cancer therapy. FGFR2 is expressed in a range of tumor types such as gastric, breast, HNSCC, pancreatic and ovarian cancers. FGFR2 has been described to promote tumor growth and survival and play a role in chemotherapy resistance.
ELISA
Immobilized human FGFR2 at 0.5 μg/ml (50 μL/well) can bind to Aprutumab with a linear range of 0.3 ng/ml-2 μg/ml.
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