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Mouse抗原名称
Amyloid beta 1-40分子别名
Amyloid-beta precursor protein, APPAccession
P05067克隆号
S-R269抗体类型
Recombinant mAb抗体同种型
IgG2b,k应用
WB反应种属 ?
Hu纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300储存条件
12 months from date of receipt / reconstitution, -20°C as supplied
| 应用 | 稀释度 |
|---|---|
| WB | 1:1000 |
Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol-dependent process and substrate presentation. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells.
免疫印迹
WB result of Amyloid beta 1-40 Mouse mAb
Primary antibody: Amyloid beta 1-40 Mouse mAb at 1/1000 dilution
Lane 1: Amyloid beta 1-42 peptide 5 ng
Lane 2: Amyloid beta 1-40 peptide 5 ng
Secondary antibody: Goat Anti-Mouse IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 4 kDa
Observed MW: <10 kDa
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