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Fc gamma RIIIa/CD16a Mouse mAb (S-564-39)

Low affinity immunoglobulin gamma Fc region receptor III-A,IgG Fc receptor III-A,CD16-II,CD16a antigen,Fc-gamma RIII-alpha,Fc-gamma RIII,FcRIII,FcRIIIa,FcgammaRIIIA,FcR-10,IgG Fc receptor III-2,FCGR3A,FCG3,FCGR3,IGFR3

Datasheet COA

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0B0348

规格

25μl100μl1ml

数量

产品介绍

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产品规格

宿主来源

Mouse
抗原名称

Fc gamma RIIIa/CD16a
分子别名

Low affinity immunoglobulin gamma Fc region receptor III-A, IgG Fc receptor III-A, CD16-II, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, FcRIII, FcRIIIa, FcgammaRIIIA, FcR-10, IgG Fc receptor III-2, FCGR3A, FCG3, FCGR3, IGFR3
免疫原

Synthetic Peptide
细胞定位

Secreted, Cell membrane
Accession

P08637
克隆号

S-564-39
抗体类型

Mouse mAb
抗体同种型

IgG1,k
反应种属 ?

Hu
纯化方式

Protein G
浓度

2 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300/
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied
应用

FCM
稀释度

应用稀释度

FCM 1:200

应用	稀释度
FCM	1:200

背景介绍

CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), which participate in signal transduction. The most well-researched membrane receptor implicated in triggering lysis by NK cells, CD16 is a molecule of the immunoglobulin superfamily (IgSF) involved in antibody-dependent cellular cytotoxicity (ADCC). It can be used to isolate populations of specific immune cells through fluorescent-activated cell sorting (FACS) or magnetic-activated cell sorting, using antibodies directed towards CD16. CD16 plays a significant role in early activation of natural killer (NK) cells following vaccination. In addition, CD16 downregulation represents a possible way to moderate NK cell responses and maintain immune homeostasis in both T cell and antibody-dependent signaling pathways.

流式分析
- Flow cytometric analysis of human PBMC (human peripheral blood mononuclear cell) labelling Fc gamma RIIIa/CD16a antibody at 1/200 (1 μg) dilution (Right) compared with a Mouse monoclonal IgG isotype control (Left). Goat Anti - Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD3 - Alexa Fluor® 647 separately.