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宿主来源
Rabbit抗原名称
CD8α分子别名
Lyt-2免疫原
Synthetic Peptide细胞定位
Cell membraneAccession
P01731克隆号
SDT-142-52抗体类型
Recombinant mAb反应种属 ?
Ms纯化方式
Protein A浓度
2 mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
应用
IF ?
稀释度
应用 稀释度 IF 1:200
CD8α encodes the CD8 alpha chain of the αβT cells, proposed as a quantifiable indicator for CD8+ CTL recruitment or activity assessments and a robust biomarker for responses to anti-PD-1/PD-L1 therapy. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
免疫荧光
IF shows positive staining in paraffin-embedded mouse thymus. Anti- CD8α (Alexa Fluor® 647 Conjugate) antibody was used at 1/200 dilution (magenta). Counterstained with DAPI (Blue). Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IF staining protocol.
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