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宿主来源
Rabbit抗原名称
Caveolin-1分子别名
CAV1免疫原
Synthetic Peptide细胞定位
Membrane, CaveolaAccession
Q03135克隆号
SDT-065-20抗体类型
Recombinant mAb应用
IF反应种属 ?
Hu, Ms, Rt纯化方式
Protein A浓度
2 mg/ml标记
Cy5性状
Liquid缓冲体系
PBS, 0.1% BSA, 0.01% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
| 应用 | 稀释度 |
|---|---|
| IF | 1:50 |
Caveolin-1 is a 22 kDa protein encoded by CAV1 gene, and occupies flask-shaped plasma membrane invaginations called caveolae. It is one of three known caveolins (CAV1, 2 and 3) and is ubiquitously expressed in all cell types as is CAV2; CAV3 is mostly found in skeletal muscles. Besides earlier studies that implicated CAV1 in endocytosis, signaling and lipid disorders, research activities in the last two decades also focused on clarifying its relevance in cancer. Caveolin-1 (Cav-1) has been considered as a master regulator among the various signaling molecules. It has been emerging as a chief protein regulating cellular events associated with homeostasis, caveolae formation, and caveolae trafficking. In addition to the physiological role of cav-1, it has a complex role in the progression of various diseases. Caveolin-1 has been identified as a prognosticator in patients with cancer and has a dual role in tumorigenesis. The expression of Cav-1 in hippocampal neurons and synapses is related to neurodegeneration, cognitive decline, and aging.
免疫荧光
IF shows positive staining in paraffin-embedded human colon. Anti-Caveolin-1 (Cy5 Conjugate) antibody was used at 1/50 dilution (magenta). Counterstained with DAPI (Blue). Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IF staining protocol.
IF shows positive staining in paraffin-embedded mouse colon. Anti-Caveolin-1 (Cy5 Conjugate) antibody was used at 1/50 dilution (magenta). Counterstained with DAPI (Blue). Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IF staining protocol.
IF shows positive staining in paraffin-embedded rat colon. Anti-Caveolin-1 (Cy5 Conjugate) antibody was used at 1/50 dilution (magenta). Counterstained with DAPI (Blue). Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IF staining protocol
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