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产品中心 诊断抗原 IVD抗原

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Human Transthyretin Protein, His Tag

ATTR,Prealbumin,TBPA,TTR,PALB

价格 ￥700.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A9067
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    ATTR, Prealbumin, TBPA, TTR, PALB

  • Accession

    P02766

  • 表达序列

    Protein sequence (P02766, Gly21-Glu147, with C-His Tag) GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 15.4 kDa Observed MW: 17, 35 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Transthyretin (TTR), also called prealbumin, is a 55-kDa tetrameric transport protein primarily synthesized in the liver and choroid plexus. It binds and transports thyroid hormones (T3/T4) and retinol (via retinol-binding protein) in blood and cerebrospinal fluid. TTR is implicated in amyloidosis, where misfolded monomers aggregate into insoluble fibrils, causing hereditary ATTR (hATTR) amyloidosis (due to mutations like V30M) or wild-type ATTR (ATTRwt) amyloidosis (age-related). These deposits lead to organ dysfunction, particularly in the heart (cardiomyopathy) and nerves (neuropathy).

  • 电泳

    • 2μg（R: reducing conditions）

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