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Human CDKN2B/p15INK4b Protein, His tag

Cyclin-dependent kinase 4 inhibitor B,Multiple tumor suppressor 2 (MTS-2),p14-INK4b,p15-INK4b (p15INK4B),MTS2

价格 ￥600.00 （ 1-2周）
货号 S0A9061
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Cyclin-dependent kinase 4 inhibitor B, Multiple tumor suppressor 2 (MTS-2), p14-INK4b, p15-INK4b (p15INK4B), MTS2

  • Accession

    P42772

  • 表达序列

    Protein sequence (P42772, Met1-Asp138, with C-His tag) MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD

  • 表达宿主

    E.coli

  • 分子量

    Predicted MW: 16.4 kDa Observed MW: 16.4 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    with C-His tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15INK4b is a protein that is encoded by the CDKN2B gene in humans. This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated, deleted, or dysregulated in a wide variety of cancer. This gene encodes a cyclin-dependent kinase inhibitor, also known as p15Ink4b protein, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases by cyclin D, thus the encoded protein functions as a cell growth regulator that inhibits cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. CDKN2B tumor suppressor gene product p15 has been shown to interact with cyclin-dependent kinase 4.

  • 电泳

    • 2μg（R: reducing conditions）

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