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Human CHOP/DDIT3 Protein, His tag

DNA damage-inducible transcript 3 protein,DDIT-3,C/EBP zeta,C/EBP-homologous protein (CHOP),C/EBP-homologous protein 10 (CHOP-10),CCAAT/enhancer-binding protein homologous protein,Growth arrest and DNA damage-inducible protein GADD153,CHOP10,GADD153

Datasheet COA

价格￥600.00 （供应商现货： 3-5个工作日）

货号 S0A9060

数量

产品介绍

产品介绍评论(0)

产品规格

物种

Human
分子别名

DNA damage-inducible transcript 3 protein, DDIT-3, C/EBP zeta, C/EBP-homologous protein (CHOP), C/EBP-homologous protein 10 (CHOP-10), CCAAT/enhancer-binding protein homologous protein, Growth arrest and DNA damage-inducible protein GADD153, CHOP10, GADD153
Accession

P35638
表达序列

Protein sequence (P35638, Met1-Ala169, with C-His tag) MAAESLPFSFGTLSSWELEAWYEDLQEVLSSDENGGTYVSPPGNEEEESKIFTTLDPASLAWLTEEEPEPAEVTSTSQSPHSPDSSQSSLAQEEEEEDQGRTRKRKQSGHSPARAGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVEATRRALIDRMVNLHQA
表达宿主

HEK293
分子量

Predicted MW: 20.9 kDa Observed MW: 33-40 kDa
纯度

＞90% by SDS-PAGE
内毒素含量

<1EU/μg
标记

Unconjugated
标签

with C-His tag
性状

Lyophilized Powder
缓冲体系

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.
溶解方法

Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
储存条件

12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

背景介绍

DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene. It is a member of the CCAAT/enhancer-binding protein (C/EBP) family of DNA-binding transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis and has an important role in the cell's stress response. The regulation of CHOP expression plays an important role in metabolic diseases and in some cancers through its function in mediating apoptosis.