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Human ferritin/FTH1 Protein, His tag

Ferritin heavy chain,Ferritin H subunit,Cell proliferation-inducing gene 15 protein,FTH,FTHL6

价格 ￥800.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A9055
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Ferritin heavy chain, Ferritin H subunit, Cell proliferation-inducing gene 15 protein, FTH, FTHL6

  • Accession

    P02794

  • 表达序列

    Protein sequence (P02794, Met1-Ser183, with C-His tag) MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES

  • 表达宿主

    E.coli

  • 分子量

    Predicted MW: 22.9 kDa Observed MW: 24 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    with C-His tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene. FTH1 gene is located on chromosome 11, and its mutation causes Hemochromatosis type 5. This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. Plasma ferritin is also an indirect marker of the total amount of iron stored in the body; hence, serum ferritin is used as a diagnostic test for iron-deficiency anemia. Aggregated ferritin transforms into a toxic form of iron called hemosiderin.

  • 生物活性

    • Immobilized Human ferritin/FTH1 Protein, His Tag at 4 μg/mL (50 μL/well) can bind Anti-Ferritin heavy chain 1/FTH1 Antibody, Mouse Monoclonal with EC50 of 8.877-10.05 ng/ml.

  • 电泳

    • 2 μg（R: reducing conditions）

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