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Rat TSH/CGA&TSHB Protein, His Tag

Thyrotropin,Thyroid-stimulating hormone

价格 ￥1,100.00 （ 1-2周）
货号 S0A8015
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Rat

  • 分子别名

    Thyrotropin, Thyroid-stimulating hormone

  • Accession

    P11962, P04652

  • 表达序列

    Protein sequence (P11962, Leu25-Ser120) LPDGDLIIQGCPECKLKENKYFSKLGAPIYQCMGCCFSRAYPTPARSKKTMLVPKNITSEATCCVAKSFTKATVMGNARVENHTDCHCSTCYYHKS Protein sequence (P04652, Phe21-Gly138, with C-His Tag) FCIPTEYMMYVDRRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFTYRTVEIPGCPHHVAPYFSYPVALSCKCGKCNTDYSDCTHEAVKTNYCTKPQTFYLGGFSG

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 10.6 kDa(CGA)&15.2 kDa(TSHB) Observed MW: 15-20 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Thyroid-stimulating hormone (TSH) is a pituitary hormone that stimulates the thyroid gland to produce thyroxine (T4), and then triiodothyronine (T3) which stimulates the metabolism of almost every tissue in the body. It is a glycoprotein hormone produced by thyrotrope cells in the anterior pituitary gland, which regulates the endocrine function of the thyroid. TSH consists of two subunits, the alpha and the beta subunit. The α subunit is thought to be the effector region responsible for stimulation of adenylate cyclase (involved the generation of cAMP). The β (beta) subunit (TSHB) is unique to TSH, and therefore determines its receptor specificity. The TSH receptor is found mainly on thyroid follicular cells. Stimulation of the receptor increases T3 and T4 production and secretion.

  • 电泳

    • 2μg（R: reducing conditions; NR: non-reducing conditions）

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