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产品中心 药物靶点和Fc受体 药物靶点

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Human C1q Protein, Flag Tag

Complement C1q

价格 ￥1,300.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A6078
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Complement C1q

  • Accession

    P02745, P02746, P02747

  • 表达序列

    Protein sequence (P02745, Glu23-Ala245) EDLCRAPDGKKGEAGRPGRRGRPGLKGEQGEPGAPGIRTGIQGLKGDQGEPGPSGNPGKVGYPGPSGPLGARGIPGIKGTKGSPGNIKDQPRPAFSAIRRNPPMGGNVVIFDTVITNQEEPYQNHSGRFVCTVPGYYYFTFQVLSQWEICLSIVSSSRGQVRRSLGFCDTTNKGLFQVVSGGMVLQLQQGDQVWVEKDPKKGHIYQGSEADSVFSGFLIFPSA Protein sequence (P02746, Gln28-Ala253) QLSCTGPPAIPGIPGIPGTPGPDGQPGTPGIKGEKGLPGLAGDHGEFGEKGDPGIPGNPGKVGPKGPMGPKGGPGAPGAPGPKGESGDYKATQKIAFSATRTINVPLRRDQTIRFDHVITNMNNNYEPRSGKFTCKVPGLYYFTYHASSRGNLCVNLMRGRERAQKVVTFCDYAYNTFQVTTGGMVLKLEQGENVFLQATDKNSLLGMEGANSIFSGFLLFPDMEA Protein sequence (P02747, Asn29-Asp245, with C-Flag Tag) NTGCYGIPGMPGLPGAPGKDGYDGLPGPKGEPGIPAIPGIRGPKGQKGEPGLPGHPGKNGPMGPPGMPGVPGPMGIPGEPGEEGRYKQKFQSVFTVTRQTHQPPAPNSLIRFNAVLTNPQGDYDTSTGKFTCKVPGLYYFVYHASHTANLCVLLYRSGVKVVTFCGHTSKTNQVNSGGVLLRLQVGEEVWLAVNDYYDMVGIQGSDSVFSGFLLFPD

  • 表达宿主

    CHO Stable Cells

  • 分子量

    Predicted MW: 23.7 kDa (C1qA)&23.7 kDa (C1qB)&22.8 kDa (C1qC) Observed MW: 24, 28, 30 kDa

  • 纯度

    ＞90% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Complement C1q is the recognition subunit of the classical complement pathway. This ~460 kDa hexameric protein has a unique "bouquet of tulips" structure, with six globular heads connected to a collagen-like stalk. Each head binds to ligands such as antibody Fc regions (IgG1, IgG2, IgG3, and IgM), pentraxins, and apoptotic cells. This binding activates C1r and C1s proteases, triggering the complement cascade that drives opsonization, inflammation, and pathogen lysis. Beyond immunity, C1q is essential for clearing apoptotic cells and immune complexes, maintaining self-tolerance. C1q deficiency is strongly linked to systemic lupus erythematosus (SLE), highlighting its critical role in immune homeostasis.

  • 生物活性

    • Immobilized Anti-CD20 Monoclonal Antibody (Rituximab) (Cat. No. S0B0570) at 10 μg/mL (100 μL/well) can bind Human C1q Protein, Flag Tag with EC50 of 0.60-0.74 μg/ml.

  • 电泳

    • 2 μg（R: reducing conditions; NR: non-reducing conditions）

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