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物种
Human分子别名
Alkaline phosphatase, germ cell type, ALP-1, Alkaline phosphatase Nagao isozyme, Alkaline phosphatase, placental-like, Germ cell alkaline phosphatase (GCAP), Placental alkaline phosphatase-like (PLAP-like), ALPPL, ALPPL2Accession
P10696表达序列
Protein sequence (P10696, Ile20-Asp503, with C-His Tag) IIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPRAGTTD
表达宿主
HEK293分子量
Predicted MW: 54.3 kDa Observed MW: 65 kDa纯度
＞95% by SDS-PAGE内毒素含量
<1EU/μg标记
Unconjugated性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
Alkaline Phosphatase, Germ Cell (GCAP) is a tissue-specific isoenzyme of alkaline phosphatase. It is primarily expressed in primordial germ cells and the placenta, making it a classic immunohistochemical marker for germ cell tumors (GCTs), such as seminomas and dysgerminomas. Its high expression in these malignancies aids in distinguishing GCTs from other cancer types. While its precise physiological role remains unclear, it is believed to be involved in cell migration and differentiation during early development. Clinically, measuring GCAP levels is valuable for diagnosing, staging, and monitoring treatment response in patients with germ cell-derived cancers.
电泳
2μg（R: reducing conditions）
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