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物种
Human分子别名
Tumor necrosis factor receptor superfamily member 6B, Decoy receptor 3 (DcR3), Decoy receptor for Fas ligand, M68, TNFRSF6B, DCR3, TR6Accession
O95407表达序列
Protein sequence (O95407, Val30-Ser195, with C-His Tag) VAETPTYPWRDAETGERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTS
表达宿主
CHO分子量
Predicted MW: 19.7 kDa Observed MW: 24 kDa
纯度
＞95% by SDS-PAGE内毒素含量
<1EU/μg标记
Unconjugated性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose.
溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
TNFRSF6B is a soluble decoy receptor that lacks a transmembrane domain and cytoplasmic tail. It neutralizes three ligands—FasL, LIGHT, and TL1A—thereby inhibiting apoptosis, lymphocyte activation, and inflammation. Overexpression of TNFRSF6B is observed in various malignancies, including lung, colon, and pancreatic cancers, where it promotes immune evasion and tumor progression. It serves as a potential biomarker for cancer diagnosis and prognosis, and is being investigated as a therapeutic target for autoimmune diseases and cancer immunotherapy.
生物活性
Immobilized Human DcR3 Protein, His Tag at 5 μg/mL (100 μL/well) can bind Human TL1A/TNFSF15 Protein, hFc Tag (Cat. No. S0A4084) with EC50 of 1.8-2.8 ng/ml.
电泳
4μg（R: reducing conditions）
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