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Human DKK-1, His tag

Dickkopf-related protein 1,Dickkopf-1,Hdkk-1,SK

价格 ￥1,560.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A6008
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Dickkopf-related protein 1, Dickkopf-1, Hdkk-1, SK

  • Accession

    O94907

  • 表达序列

    Protein sequence(O94907, Thr32-His266, with C-10*His) TLNSVLNSNAIKNLPPPLGGAAGHPGSAVSAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKRRKRCMRHAMCCPGNYCKNGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRHGGGGSHHHHHHHHHH

  • 表达宿主

    HEK293

  • 分子量

    Theoretical: 27.4kDa Actual: 45kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 ℃ to -70 °C as supplied.

    1 month, 2 to 8 °C under sterile conditions after reconstitution.

    Please avoid repeated freeze-thaw cycles.

背景介绍

  • DKK-1 is a member of the dickkopf family and is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the Wnt signaling pathway. DKK-1 is an antagonist of the Wnt/β-catenin signalling pathway that acts by isolating the LRP6 co-receptor so that it cannot aid in activating the WNT signaling pathway. Moreover, DKK-1 was demonstrated to antagonize the Wnt/β-catenin pathway via a reduction in β-catenin and an increase in OCT4 expression.This inhibition plays a key role in heart, head and forelimb development during anterior morphogenesis of the embryo. Elevated levels of DKK-1 in bone marrow, plasma and peripheral blood are associated with the presence of osteolytic bone lesions in patients with multiple myeloma. Due to the role of DKK-1 in inflammation induced bone loss DKK-1 is under investigation as target for therapeutic strategies in medicine and dentistry.

  • 生物活性

    • Immobilized Human DKK-1, His tag at 1 μg/mL (50 μL/well) can bind DKK-1 Recombinant Rabbit mAb (SDT-232-288) (Cat. No. S0B3276) with EC50 of 8.520-9.722 ng/ml.

  • 电泳

    • 2μg（R: reducing conditions）

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