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Human IGFBP-4 Protein, His Tag

Insulin-like growth factor-binding protein 4,IBP-4,IGF-binding protein 4,IGFBP-4,IGFBP4,IBP4

价格 ￥3,800.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A6002
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Insulin-like growth factor-binding protein 4, IBP-4, IGF-binding protein 4, IGFBP-4, IGFBP4, IBP4

  • Accession

    P22692

  • 表达序列

    Protein sequence (P22692, Asp22-Glu258, with C-His Tag) DEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFRE

  • 分子量

    Predicted MW: 27.7 kDa Observed MW: 30-35 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • IGFBP-4 (insulin-like growth factor binding protein 4) binds to insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF effects in vitro. All members of the IGFBP family bind to IGF-I and IGF-II with approximately equal affinity, but IGFBP-4 binds to IGF2 better than IGF1. It contains a N-terminal domain of IGFBP and a thyroglobulin 1 type domain. IGFBP prolongs the half-life of insulin-like growth factor and has been shown to inhibit or stimulate the stimulative effects of insulin-like growth factor on cell culture. They alter the interaction of IGF with its cell surface receptors. IGFBP-4 is a unique protein that consistently inhibits multiple cancer cells in vivo and in vitro.This product is the recombinant human IGFBP-4 protein expressed from human 293 cells (HEK293).

  • 生物活性

    • Immobilized Human IGFBP-4 Protein, His Tag at 2 μg/mL (50 μL/well) can bind Human IGF-2 Protein, hFc Tag (Cat. No. S0A4045) with EC50 of 39.02-43.08 ng/ml.

  • 电泳

    • 1μg（R: reducing conditions）

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