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产品中心 细胞因子 白细胞介素

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Cynomolgus IL-6 Protein, His Tag

Interleukin-6,IL6

价格 ￥800.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A4085
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Cynomolgus

  • 分子别名

    Interleukin-6, IL6

  • Accession

    P79341

  • 表达序列

    Protein sequence (P79341, Ala28-Met212, with C-His Tag) APVLPGEDSKDVAAPHSQPLTSSERIDKHIRYILDGISALRKETCNRSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEDTCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPEPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM

  • 分子量

    Predicted MW: 22.7 kDa Observed MW: 24-30 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. Osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory myokine is mediated through its inhibitory effects on TNF-alpha and IL-1 and its activation of IL-1ra and IL-10. IL-6 stimulates the inflammatory and auto-immune processes in many diseases such as multiple sclerosis, diabetes, atherosclerosis, depression, Alzheimer's disease, systemic lupus erythematosus, multiple myeloma, prostate cancer, rheumatoid arthritis, and intracerebral hemorrhage.

  • 生物活性

    • Immobilized Cynomolgus IL-6 Protein, His Tag at 5 μg/mL (100 μL/well) can bind Biotinylated IL-6 R alpha/CD126 Fc&Avi Tag Protein, Human (UA011222) with EC50 of 17.13-29.83 ng/ml.

  • 电泳

    • 2μg（R: reducing conditions）

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