热搜词：
注册
登录
CN
  • CN
  • EN

产品中心 细胞因子 肿瘤坏死因子

所有图片（1/2）

Human TL1A/TNFSF15 Protein, His Tag

Tumor necrosis factor ligand superfamily member 15,TNF ligand-related molecule 1,Vascular endothelial cell growth inhibitor,TL1,VEGI

价格 ￥1,200.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A4083
规格
数量
收藏 分享
产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1, Vascular endothelial cell growth inhibitor, TL1, VEGI

  • Accession

    O95150-1

  • 表达序列

    Protein sequence (O95150-1, Leu72-Leu251, with N-His Tag) LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 22.2 kDa Observed MW: 25-30 kDa

  • 纯度

    ＞90% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • TNFSF15 (Tumor Necrosis Factor Superfamily Member 15), also known as TL1A, is a cytokine that binds to death receptor 3 (DR3) and decoy receptor 3 (DcR3). It plays a key role in modulating immune responses, particularly in T-cell activation, inflammation, and autoimmune diseases. TNFSF15 is highly expressed in endothelial cells and contributes to angiogenesis and vascular remodeling. Dysregulation of TNFSF15 is linked to inflammatory disorders (e.g., Crohn’s disease, rheumatoid arthritis) and cancers. Its dual role in pro-inflammatory and anti-angiogenic signaling makes it a potential therapeutic target for immune-mediated and vascular diseases.

  • 生物活性

    • Immobilized Human TL1A/TNFSF15 Protein, His Tag at 5 μg/mL (100 μL/well) can bind Biotinylated Human DcR3/TNFRSF6B Protein, His Tag&Avi Tag with EC50 of 13.2-15.0 ng/ml.

  • 电泳

    • 2μg（R: reducing conditions）

评论(0)