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产品中心 细胞因子 白细胞介素

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Human IL-5 Protein, His Tag

Interleukin-5,B-cell differentiation factor I,Eosinophil differentiation factor,T-cell replacing factor (TRF),IL5

价格 ￥1,000.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A4082
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Interleukin-5, B-cell differentiation factor I, Eosinophil differentiation factor, T-cell replacing factor (TRF), IL5

  • Accession

    P05113

  • 表达序列

    Protein sequence (P05113, Ile20-Ser134, with N-His Tag) IPTEIPTSALVKETLALLSTHRTLLIANETLRIPVPVHKNHQLCTEEIFQGIGTLESQTVQGGTVERLFKNLSLIKKYIDGQKKKCGEERRRVNQFLDYLQEFLGVMNTEWIIES

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 15.4 kDa Observed MW: 20 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Interleukin-5 (IL-5) is a crucial cytokine primarily produced by type 2 helper T (Th2) cells and group 2 innate lymphoid cells (ILC2s). Its principal biological function is to regulate the growth, differentiation, recruitment, and survival of eosinophils, a type of white blood cell central to immune responses against parasitic infections, particularly helminths. IL-5 also plays a significant role in allergic diseases, such as asthma and atopic dermatitis, by promoting eosinophilia and IgE production. Furthermore, it supports the maturation and antibody secretion of B cells. Due to its pivotal role in eosinophil-mediated inflammation, IL-5 and its receptor are major therapeutic targets for monoclonal antibody treatments in severe eosinophilic asthma and other hypereosinophilic syndromes.

  • 生物活性

    • Immobilized Human IL-5 Protein, His Tag at 5 μg/mL (100 μL/well) can bind Human IL-5 R alpha / CD125 Protein, Fc Tag with EC50 of 13.4-16.6 ng/ml.

  • 电泳

    • 2μg（R: reducing conditions）

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