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物种
Human分子别名
Interleukin-31, IL31Accession
Q6EBC2表达序列
Protein sequence (Q6EBC2, Ser24-Thr164, with N-His Tag) SHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT
表达宿主
HEK293分子量
Predicted MW: 17.5 kDa Observed MW: 20 kDa纯度
＞95% by SDS-PAGE内毒素含量
<1EU/μg标记
Unconjugated性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
Interleukin-31 (IL-31) is a novel cytokine belonging to the IL-6 family, primarily produced by activated T helper 2 (Th2) cells and mast cells. It signals through a heterodimeric receptor composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor β (OSMRβ), which is expressed on various cell types including sensory neurons, keratinocytes, and immune cells. IL-31 is a key mediator of pruritus (itch) in inflammatory skin diseases such as atopic dermatitis, psoriasis, and allergic conditions. Its signaling pathway promotes itch sensation, disrupts epidermal barrier function, and drives immune responses, making it a significant therapeutic target for chronic pruritic disorders.
生物活性
Immobilized Human IL-31 Protein, His Tag at 1 μg/mL (100 μL/well) can bind Human IL-31 RA Protein, Fc Tag with EC50 of 0.11-0.15 μg/ ml.
电泳
2μg（R: reducing conditions）
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