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产品中心 细胞因子 白细胞介素

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Mouse IL-17A Protein, His tag

Interleukin-17A,IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8),Il17a,Ctla8,Il17

价格 ￥820.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A4070
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 分子别名

    Interleukin-17A, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8), Il17a, Ctla8, Il17

  • Accession

    Q62386

  • 表达序列

    Protein sequence (Q62386, Thr22-Ala158, with C-His tag) TVKAAAIIPQSSACPNTEAKDFLQNVKVNLKVFNSLGAKVSSRRPSDYLNRSTSPWTLHRNEDPDRYPSVIWEAQCRHQRCVNAEGKLDHHMNSVLIQQEILVLKREPESCPFTFRVEKMLVGVGCTCVASIVRQAA

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 17.1 kDa Observed MW: 17-25 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    with C-His tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • IL-17A is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappa B and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

  • 生物活性

    • Immobilized Mouse IL-17A Protein, His tag at 2 μg/mL (100 μL/well) can bind Recombinant Mouse IL-17RA/CD217 Protein with EC50 of 23.6-35.6 ng/ml.

  • 电泳

    • 2μg（R: reducing conditions）

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