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产品中心 细胞因子 干扰素

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Rat IFN-γ Protein, His tag

Interferon gamma,IFN-gamma,Ifng

价格 ￥950.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A4046
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Rat

  • 分子别名

    Interferon gamma, IFN-gamma, Ifng

  • Accession

    P01581

  • 表达序列

    Protein sequence (P01581, Met1-Cys156, with C-His tag) MSATRRVLVLQLCLMALSGCYCQGTLIESLESLKNYFNSSSMDAMEGKSLLLDIWRNWQKDGNTKILESQIISFYLRLFEVLKDNQAISNNISVIESHLITNFFSNSKAKKDAFMSIAKFEVNNPQIQHKAVNELIRVIHQLSPESSLRKRKRSRC

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 19.6 kDa Observed MW: 19-25 kDa

  • 纯度

    ＞90% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    with C-His tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Interferon gamma (IFNG or IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. Through cell signaling, interferon gamma plays a role in regulating the immune response of its target cell. A key signaling pathway that is activated by type II IFN is the JAK-STAT signaling pathway. IFNG plays an important role in both innate and adaptive immunity. Type II IFN is primarily secreted by adaptive immune cells, more specifically CD4+ T helper 1 (Th1) cells, natural killer (NK) cells, and CD8+ cytotoxic T cells. The expression of type II IFN is upregulated and downregulated by cytokines. By activating signaling pathways in cells such as macrophages, B cells, and CD8+ cytotoxic T cells, it is able to promote inflammation, antiviral or antibacterial activity, and cell proliferation and differentiation. Type II IFN has played a role in the development of cancer immunotherapy treatments due to its ability to prevent tumor growth.

  • 生物活性

    • Immobilized Rat IFN-γ Protein, His tag at 4 μg/mL (50 μL/well) can bind Recombinant Mouse IFNGR1 (C-Fc) with EC50 of 28.22-36.34 ng/ml.

  • 电泳

    • 2 μg（R: reducing conditions）

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