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产品中心 细胞因子 白细胞介素

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Human IL-15 Protein, hFc tag

Interleukin-15,IL15

价格 ￥1,350.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A4044
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Interleukin-15, IL15

  • Accession

    P40933

  • 表达序列

    Protein sequence (P40933, Asn49-Ser162, with C-hFc tag) NWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 38.8 kDa Observed MW: 45-60 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    with C-hFc tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2 (IL-2). Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces the proliferation of natural killer cells, i.e. cells of the innate immune system whose principal role is to kill virally infected cells. IL-15 is constitutively expressed by a large number of cell types and tissues, including monocytes, macrophages, dendritic cells (DC), keratinocytes, fibroblasts, myocyte and nerve cells. As a pleiotropic cytokine, it plays an important role in innate and adaptive immunity.

  • 生物活性

    • Immobilized Human IL-15 Protein, hFc tag at 4 μg/mL (50 μL/well) can bind Biotinylated IL-15R alpha/CD215 Fc&Avi Tag, Human (Cat. No. UA010693) with EC50 of 1.259-1.656 ng/ml.

  • 电泳

    • 2 μg（R: reducing conditions）

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