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产品中心 细胞因子 白细胞介素

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Human IL-13 Protein, His Tag

NC30

价格 ￥1,200.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A4025
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    NC30

  • Accession

    P35225

  • 表达序列

    Protein sequence (P35225, Gly35-Asn146, with C-His Tag) GPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN

  • 分子量

    Predicted MW: 14 kDa Observed MW: 25-35 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/mg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with a length of 1.4kb. It has a mass of 13 kDa and folds into 4 alpha helical bundles. The secondary structural features of IL-13 are similar to that of Interleukin 4 (IL-4); however it only has 25% sequence identity to IL-4 and is capable of IL-4 independent signaling. IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, eosinophils and nuocytes. Interleukin-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis and chitinase up-regulation. It is a mediator of allergic inflammation and different diseases including asthma.

  • 生物活性

    • Immobilized Human IL-13 Protein, His Tag at 5 μg/mL (100 μL/well) can bind Human IL-13 R alpha 2 Protein, Fc Tag with EC50 of 3.64-5.64 ng/ ml.

  • 电泳

    • 2μg（R: reducing conditions）

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