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Human IL-6, His tag

B-cell stimulatory factor 2 (BSF-2),CTL differentiation factor (CDF),Hybridoma growth factor,Interferon beta-2 (IFN-beta-2)

价格 ￥1,200.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A4011
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    B-cell stimulatory factor 2 (BSF-2), CTL differentiation factor (CDF), Hybridoma growth factor, Interferon beta-2 (IFN-beta-2)

  • Accession

    P05231

  • 表达序列

    Protein sequence(P05231, Val30-Met212, with C-10*His)
    VPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQMGGGGSHHHHHHHHHH

  • 表达宿主

    HEK293

  • 分子量

    Theoretical: 22.4kDa Actual: 22-23kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 ℃ to -70 °C as supplied.

    1 month, 2 to 8 °C under sterile conditions after reconstitution.

    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Interleukin 6 (IL-6) is a prototypical cytokine for maintaining homeostasis. When homeostasis is disrupted by infections or tissue injuries, IL-6 is produced immediately and contributes to host defense against such emergent stress through activation of acute-phase and immune responses. However, dysregulated excessive and persistent synthesis of IL-6 has a pathological effect on, respectively, acute systemic inflammatory response syndrome and chronic immune-mediated diseases.

  • 生物活性

    • The ELISA based assay shows that Human IL-6, His tag is stable at 4°C for 4 weeks.

    • Immobilized Human IL-6, His tag at 4 μg/mL (50 μL/well) can bind IL-6R alpha/CD126 Fc Chimera, Human (UA010448) with EC50 of 9.425-12.74 ng/ml.

    • The ELISA based assay shows that Human IL-6, His tag is stable after freezing and thawing 3 times.

    • Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 for this effect is 0.2-0.9 ng/mL.

  • 电泳

    • 2μg（R: reducing conditions）

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