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产品中心 药物靶点和Fc受体 药物靶点

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Human RET Protein, His Tag

Proto-oncogene tyrosine-protein kinase receptor Ret,Cadherin family member 12,Proto-oncogene c-Ret,CDHF12,CDHR16,PTC

价格 ￥1,000.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A2224
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Proto-oncogene tyrosine-protein kinase receptor Ret, Cadherin family member 12, Proto-oncogene c-Ret, CDHF12, CDHR16, PTC

  • Accession

    P07949

  • 表达序列

    Protein sequence (P07949, Leu29-Arg635, with C-His Tag) LYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCR

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 69.5 kDa Observed MW: 100-120 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • The RET is a receptor tyrosine kinase crucial for normal cell development and survival. It is activated by binding to glial cell line-derived neurotrophic factor (GDNF) family ligands, leading to dimerization and autophosphorylation. This triggers downstream signaling pathways like MAPK and PI3K-AKT, which regulate proliferation, differentiation, and migration, particularly in neural crest and genitourinary lineages. Gain-of-function mutations in RET cause constitutive activation, driving oncogenesis in medullary thyroid cancer and other malignancies. Conversely, loss-of-function mutations are associated with developmental disorders like Hirschsprung's disease. RET is thus a critical therapeutic target in both oncology and neurodevelopment.

  • 电泳

    • 2μg（R: reducing conditions）

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