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物种
Human分子别名
Natural cytotoxicity triggering receptor 1, Lymphocyte antigen 94 homolog, NK cell-activating receptor, Natural killer cell p46-related protein (NK-p46; NKp46; hNKp46), CD335, NCR1, LY94Accession
O76036表达序列
Protein sequence (O76036, Gln22-Gln254, with C-His Tag) QQQTLPKPFIWAEPHFMVPKEKQVTICCQGNYGAVEYQLHFEGSLFAVDRPKPPERINKVQFYIPDMNSRMAGQYSCIYRVGELWSEPSNLLDLVVTEMYDTPTLSVHPGPEVISGEKVTFYCRLDTATSMFLLLKEGRSSHVQRGYGKVQAEFPLGPVTTAHRGTYRCFGSYNNHAWSFPSEPVKLLVTGDIENTSLAPEDPTFPADTWGTYLLTTETGLQKDHALWDHTAQ
表达宿主
HEK293分子量
Predicted MW: 28.1 kDa Observed MW: 40 kDa纯度
＞95% by SDS-PAGE内毒素含量
<1EU/μg标记
Unconjugated性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
Natural Cytotoxicity Triggering Receptor 1 (NCR1), also known as CD335 or NKp46, is a type I transmembrane glycoprotein primarily expressed on the surface of natural killer (NK) cells and a subset of innate lymphoid cells. It serves as a pivotal activating receptor crucial for innate immune responses. As a member of the Natural Cytotoxicity Receptor (NCR) family, CD335 plays a key role in target cell recognition and the subsequent cytolytic activity against virus-infected and tumor cells. Its engagement triggers the release of cytotoxic granules and inflammatory cytokines, making it essential for early defense mechanisms. The receptor is considered a specific marker for NK cell identification in humans and other species.
电泳
2μg（R: reducing conditions）
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