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Human CD39, His tag

Ecto-ATP diphosphohydrolase 1 (Ecto-ATPDase 1,Ecto-ATPase 1),Ecto-apyrase,Lymphoid cell activation antigen,CD39

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A1082
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Ecto-ATP diphosphohydrolase 1 (Ecto-ATPDase 1; Ecto-ATPase 1), Ecto-apyrase, Lymphoid cell activation antigen, CD39

  • Accession

    P49961

  • 表达序列

    Protein sequence (P49961, Lys41-His474, with C-10*His) KALPENVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHGGGGSHHHHHHHHHH

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 51.2 kDa Observed MW: 60-75 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 标签

    with C-10*His

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

  • 溶解方法

    Reconstitute no more than 1 mg/ml according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.

背景介绍

  • Ectonucleoside triphosphate diphosphohydrolase-1 (gene: ENTPD1; protein: NTPDase1) also known as CD39 (Cluster of Differentiation 39), is a typical cell surface enzyme with a catalytic site on the extracellular face. ATP causes a pro-inflammatory environment, whereas degradation of ATP into adenosine by the CD39/CD73 pathway leads to an anti-inflammatory environment. Adenosine produced by the CD39/CD73 pathway can protect against ischemia-reperfusion injury. High expression and activity of CD39 and CD73 on cancer cells can prevent the immune system from inhibiting the progression of cancer. Biallelic pathogenic variant in ENTPD1 causes autosomal recessive spastic paraplegia 64 (SPG64).

  • 生物活性

    • Immobilized Human CD39, His tag at 2 μg/mL (50 μL/well) can bind CD39 Recombinant Rabbit mAb (SDT-236-20) (S0B0050) with EC50 of 4.144-6.107 ng/ml.

  • 电泳

    • 2μg（R: reducing conditions）

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