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产品中心 诊断抗原 CD分子抗原

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Human CD47, hFc tag

Antigenic surface determinant protein OA3,Integrin-associated protein (IAP),Protein MER6,MER6

价格 ￥250.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A1052
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Antigenic surface determinant protein OA3, Integrin-associated protein (IAP), Protein MER6, MER6

  • Accession

    Q08722

  • 表达宿主

    HEK293

  • 分子量

    Theoretical:40kDa Actual:65kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/mg

  • 标签

    with C-hFc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, 1mM EDTA, pH7.4.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.

背景介绍

  • CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis. CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. Expression in equine cutaneous tumors has been reported as well.

  • 生物活性

    • Immobilized SIRP-α His Tag, Human (UA010009) at 20 μg/mL (50 μL/well) can bind Human CD47, hFc tag with EC50 of 12.25-18.23 ng/mL.

  • 电泳

    • 2μg（R: reducing conditions）

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