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产品中心 诊断抗原 CD分子抗原

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Human CD47, His tag

Antigenic surface determinant protein OA3,Integrin-associated protein (IAP),Protein MER6

价格 ￥400.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A1045
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Antigenic surface determinant protein OA3, Integrin-associated protein (IAP), Protein MER6

  • Accession

    Q08722

  • 表达序列

    Protein sequence(Q08722, Gln19-Glu141, with C-10*His) QLLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTELTREGETIIELKYRVVSWFSPNEGGGGSHHHHHHHHHH

  • 表达宿主

    HEK293

  • 分子量

    Theoretical:15.6kDa Actual:30-45kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 标签

    with C-10*His

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.

背景介绍

  • CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily[5] and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis. CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells.

  • 生物活性

    • Immobilized SIRP-α Fc Chimera, Human (UA010005) at 4 μg/mL (50 μL/well) can bind Human CD47, His tag with EC50 of 29.30-41.04 ng/mL.

  • 电泳

    • 2μg（R: reducing conditions）

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