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Human CD19, His tag

B-lymphocyte surface antigen B4,Differentiation antigen CD19,T-cell surface antigen Leu-12

价格 ￥900.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A1011
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12

  • Accession

    P15391

  • 表达序列

    Protein sequence(P15391, Arg19-Thr287, with C-10*His)
    RPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGGGSHHHHHHHHHH

  • 表达宿主

    HEK293

  • 分子量

    Theoretical: 31.5kDa Actual: 45-53kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 ℃ to -70 °C as supplied.

    1 month, 2 to 8 °C under sterile conditions after reconstitution.

    Please avoid repeated freeze-thaw cycles.

背景介绍

  • B-lymphocyte antigen CD19 is a transmembrane protein that in humans is encoded by the gene CD19, This gene encodes a member of the immunoglobulin gene superfamily. In humans, CD19 is expressed in all B lineage cells. Contrary to some early doubts, human plasma cells do express CD19, as confirmed by others. CD19 plays two major roles in human B cells: on the one hand, it acts as an adaptor protein to recruit cytoplasmic signaling proteins to the membrane; on the other, it works within the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Due to its presence on all B cells, it is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for leukemia immunotherapies.

  • 生物活性

    • Immobilized Human CD19, His tag at 1 μg/mL (50 μL/well) can bind CD19 Recombinant Rabbit mAb (SDT-164-41) (S0B2213) with EC50 of 5.009-6.031 ng/mL.

  • 电泳

    • 2μg (R: reducing conditions)

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