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物种
Human分子别名
Sialic acid-binding Ig-like lectin 3 (Siglec-3), gp67Accession
P20138表达序列
Protein sequence(P20138, Asp18-His259, with C-10*His)
DPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPIFSWLSAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLNVTYVPQNPTTGIFPGDGSGKQETRAGVVHGGGGSHHHHHHHHHH表达宿主
HEK293分子量
Theoretical: 28.5kDa Actual: 45kDa纯度
＞95% by SDS-PAGE
内毒素含量
<1EU/μg标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 ℃ to -70 °C as supplied. 1 month,
2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
CD33 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. The level of CD33 was found to be increased in the AD brain, which positively correlated with amyloid plaque burden and disease severity. More importantly, CD33 led to the impairment of microglia-mediated clearance of Aβ, which resulted in the formation of amyloid plaques in the brain.
生物活性
Immobilized Human CD33, His Tag at 2 μg/mL (50 μL/well) can bind CD33 Recombinant Rabbit mAb (SDT-269-171) (S0B2209) with EC50 of 3.718-5.786 ng/mL.
电泳
- 2μg (R: reducing conditions)
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