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产品中心 药物靶点和Fc受体 药物靶点

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Human STAB1 Protein, hFc Tag

Stabilin-1,Fasciclin,EGF-like,laminin-type EGF-like and link domain-containing scavenger receptor 1 (FEEL-1),MS-1 antigen,FEEL1,KIAA0246

价格 ￥600.00 （ 1-2周）
货号 S0A0226
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Stabilin-1, Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1 (FEEL-1), MS-1 antigen, FEEL1, KIAA0246

  • Accession

    Q9NY15

  • 表达序列

    Protein sequence (Q9NY15, Asp638-Leu1024, with C-hFc tag) DGILLPPTILPILPKHCSEEQHKIVAGSCVDCQALNTSTCPPNSVKLDIFPKECVYIHDPTGLNVLKKGCASYCNQTIMEQGCCKGFFGPDCTQCPGGFSNPCYGKGNCSDGIQGNGACLCFPDYKGIACHICSNPNKHGEQCQEDCGCVHGLCDNRPGSGGVCQQGTCAPGFSGRFCNESMGDCGPTGLAQHCHLHARCVSQEGVARCRCLDGFEGDGFSCTPSNPCSHPDRGGCSENAECVPGSLGTHHCTCHKGWSGDGRVCVAIDECELDMRGGCHTDALCSYVGPGQSRCTCKLGFAGDGYQCSPIDPCRAGNGGCHGLATCRAVGGGQRVCTCPPGFGGDGFSCYGDIFRELEANAHFSIFYQWLKSAGITLPADRRVTAL

  • 分子量

    Predicted MW: 67.5 kDa Observed MW: 70-95 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Stabilin-1 is a large transmembrane glycoprotein primarily expressed on macrophages, sinusoidal endothelial cells (e.g., in liver and spleen), and certain tumor-associated macrophages. It functions as a scavenger receptor and endocytic receptor, mediating the clearance of various ligands from blood and tissue fluids, including acetylated/low-density lipoproteins, advanced glycation end-products (AGEs), and apoptotic cells. By removing harmful molecules and cellular debris, Stabilin-1 contributes to tissue homeostasis, inflammation resolution, and immune regulation. It is also involved in cell adhesion, angiogenesis, and lymphatic vessel development. Dysregulation of Stabilin-1 has been linked to inflammatory diseases, atherosclerosis, and cancer progression, as it facilitates immune evasion in tumors.

  • 电泳

    • 2μg（R: reducing conditions）

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