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产品中心 药物靶点和Fc受体 药物靶点

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Human EGF R Protein, hFc Tag

Epidermal growth factor receptor,Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1,ERBB,ERBB1,HER1,EGFR

价格 ￥600.00 （ 1-2周）
货号 S0A0224
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, ERBB, ERBB1, HER1, EGFR

  • Accession

    P00533-1

  • 表达序列

    Protein sequence (P00533-1, Leu25-Ser645, with C-hFc Tag) LEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPS

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 95.5 kDa Observed MW: 120-130 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • The Epidermal Growth Factor Receptor (EGFR) is a transmembrane tyrosine kinase receptor belonging to the ErbB family. Upon binding to its ligands such as EGF or TGF-α, EGFR undergoes homo- or hetero-dimerization, triggering autophosphorylation of intracellular tyrosine residues and activation of downstream signaling cascades including MAPK/ERK, PI3K/AKT, and JAK/STAT pathways. These regulate critical cellular processes including proliferation, survival, migration, and differentiation. EGFR is frequently overexpressed, amplified, or mutated in various cancers, particularly non-small cell lung cancer (NSCLC), colorectal cancer, and glioblastoma.

  • 生物活性

    • Immobilized HB-EGF Protein, Human (Cat. No. UA040500) at 5 μg/mL (100 μL/well) can bind Human EGF R Protein, hFc Tag with EC50 of 0.88-1.14 ng/ml.

  • 电泳

    • 2μg（R: reducing conditions）

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