Human BACE2 Protein, His Tag
Beta-secretase 2,Aspartic-like protease 56 kDa,Aspartyl protease 1 (ASP1,Asp 1),Beta-site amyloid precursor protein cleaving enzyme 2 (Beta-site APP cleaving enzyme 2),Down region aspartic protease (DRAP),Memapsin-1,Membrane-associated aspartic protease 1,Theta-secretase,AEPLC,ALP56,ASP21
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物种
Human分子别名
Beta-secretase 2, Aspartic-like protease 56 kDa, Aspartyl protease 1 (ASP1; Asp 1), Beta-site amyloid precursor protein cleaving enzyme 2 (Beta-site APP cleaving enzyme 2), Down region aspartic protease (DRAP), Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase, AEPLC, ALP56, ASP21Accession
Q9Y5Z0表达序列
Protein sequence (Q9Y5Z0, Ala21-Pro466, with C-His Tag) APELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEP
表达宿主
HEK293分子量
Predicted MW: 49.6 kDa Observed MW: 55 kDa纯度
＞95% by SDS-PAGE内毒素含量
<1EU/μg标记
Unconjugated性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
Beta-secretase 2 (BACE2) is an aspartic protease encoded by a gene located on chromosome 21. It is expressed in various peripheral tissues and, to a lesser extent, in the central nervous system. Unlike its role in amyloid precursor protein (APP) processing, BACE2 primarily cleaves APP within the amyloid-beta domain, an action that may limit amyloid-beta peptide production. Its physiological functions extend to processes such as pancreatic beta-cell maintenance, skin pigmentation regulation, and skeletal muscle homeostasis. Research into BACE2 is also significant in the context of Down syndrome, due to the gene dosage effect associated with its chromosomal location.
电泳
2μg（R: reducing conditions）
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