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物种
Human分子别名
Non-secretory ribonuclease, Eosinophil-derived neurotoxin, RNase UpI-2, Ribonuclease 2 (RNase 2), Ribonuclease US, EDN, RNS2Accession
P10153表达序列
Protein sequence (P10153, Lys28-Ile161, with C-His Tag) KPPQFTWAQWFETQHINMTSQQCTNAMQVINNYQRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNISNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII
表达宿主
HEK293分子量
Predicted MW: 17.2 kDa Observed MW: 30-40 kDa纯度
＞95% by SDS-PAGE内毒素含量
<1EU/μg标记
Unconjugated性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
RNASE2, commonly known as Eosinophil-Derived Neurotoxin (EDN), is a secretory protein belonging to the RNase A superfamily. It is abundantly expressed in and secreted by eosinophils, a type of white blood cell. While it exhibits ribonuclease activity, its primary biological significance lies in its potent anti-pathogen and immunomodulatory functions. RNASE2 displays broad antiviral activity against single-stranded RNA viruses and possesses neurotoxic properties in vitro. It acts as an endogenous ligand for Toll-like receptor 2 (TLR2), thereby promoting dendritic cell-mediated adaptive Th2 immune responses. Its levels are clinically significant as a biomarker for eosinophil activation in diseases such as asthma, allergies, and helminth infections.
电泳
2μg（R: reducing conditions）
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