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物种
Human分子别名
Neuronal pentraxin-2, NP2, Neuronal pentraxin II (NP-II)Accession
P47972表达序列
Protein sequence (P47972, Gly16-Leu431, with C-His Tag) GAQDSPAPGSRFVCTALPPEAVHAGCPLPAMPMQGGAQSPEEELRAAVLQLRETVVQQKETLGAQREAIRELTGKLARCEGLAGGKARGAGATGKDTMGDLPRDPGHVVEQLSRSLQTLKDRLESLEHQLRANVSNAGLPGDFREVLQQRLGELERQLLRKVAELEDEKSLLHNETSAHRQKTESTLNALLQRVTELERGNSAFKSPDAFKVSLPLRTNYLYGKIKKTLPELYAFTICLWLRSSASPGIGTPFSYAVPGQANEIVLIEWGNNPIELLINDKVAQLPLFVSDGKWHHICVTWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVLILGQEQDTVGGRFDATQAFVGELSQFNIWDRVLRAQEIVNIANCSTNMPGNIIPWVDNNVDVFGGASKWPVETCEERLLDL
表达宿主
HEK293分子量
Predicted MW: 47.4 kDa Observed MW: 55-70 kDa纯度
＞95% by SDS-PAGE内毒素含量
<1EU/μg标记
Unconjugated性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
Neuronal Pentraxin 2 (NPTX2), also known as Neuronal Activity-Regulated Pentraxin (NARP), is a secreted protein predominantly expressed in neurons. It belongs to the pentraxin family and is rapidly induced by synaptic activity. Its primary function is at excitatory synapses, where it organizes the surface expression of AMPA-type glutamate receptors. By clustering these receptors, NPTX2 is crucial for strengthening synaptic connections and is a key mediator of homeostatic and experience-dependent plasticity. Dysregulation of NPTX2 is increasingly associated with various neurological disorders, including cognitive impairment, Alzheimer's disease, and schizophrenia.
电泳
2μg（R: reducing conditions）
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