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Human CCL8 Protein, His Tag

C-C motif chemokine 8,HC14,Monocyte chemoattractant protein 2,Monocyte chemotactic protein 2 (MCP-2),Small-inducible cytokine A8,MCP2,SCYA10,SCYA8

价格 ￥600.00 （ 1-2周）
货号 S0A0213
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    C-C motif chemokine 8, HC14, Monocyte chemoattractant protein 2, Monocyte chemotactic protein 2 (MCP-2), Small-inducible cytokine A8, MCP2, SCYA10, SCYA8

  • Accession

    P80075

  • 表达序列

    Protein sequence (P80075, Met1-Pro99, with C-His Tag) MKVSAALLCLLLMAATFSPQGLAQPDSVSIPITCCFNVINRKIPIQRLESYTRITNIQCPKEAVIFKTKRGKEVCADPKERWVRDSMKHLDQIFQNLKP

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 10.6 kDa Observed MW: 11 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • CCL8, also known as Monocyte Chemoattractant Protein-2 (MCP-2), is a small cytokine belonging to the CC chemokine family. It is produced by various cells, including monocytes, fibroblasts, and endothelial cells, often in response to inflammatory stimuli. Its primary function is to recruit immune cells to sites of inflammation or infection by binding to several receptors, most notably CCR1, CCR2, CCR5, and CCR8. Through these interactions, CCL8 directs the migration of monocytes, lymphocytes, eosinophils, and dendritic cells. CCL8 plays a significant role in both antimicrobial defense and the pathogenesis of various diseases. It is implicated in chronic inflammatory conditions, allergic responses, and cancer, where it can influence tumor progression and the tumor microenvironment.

  • 电泳

    • 2μg（R: reducing conditions）

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