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Human SP-A1 Protein, His Tag

Pulmonary surfactant-associated protein A1,PSP-A,PSPA,SP-A,SP-A1,35 kDa pulmonary surfactant-associated protein,Alveolar proteinosis protein,Collectin-4,COLEC4,PSAP,SFTP1,SFTPA,SFTPA1B,SFTPA1

Datasheet COA

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货号 S0A0203

数量

产品介绍

产品介绍评论(0)

产品规格

物种

Human
分子别名

Pulmonary surfactant-associated protein A1, PSP-A, PSPA, SP-A, SP-A1, 35 kDa pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-4, COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B, SFTPA1
Accession

Q8IWL2
表达序列

Protein sequence (Q8IWL2, Glu21-Phe248, with C-His Tag) EVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF
表达宿主

HEK293
分子量

Predicted MW: 25.9 kDa Observed MW: 35 kDa
纯度

＞95% by SDS-PAGE
内毒素含量

<1EU/μg
标记

Unconjugated
性状

Lyophilized Powder
缓冲体系

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
溶解方法

Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
储存条件

12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

背景介绍

Surfactant Protein A1 (SFTPA1) is a critical component of pulmonary surfactant, primarily produced by alveolar type II cells in the lungs. It belongs to the collectin family and plays a vital role in innate immune defense. SFTPA1 binds to pathogens, facilitating their opsonization and clearance by alveolar macrophages. Beyond host defense, it is essential for maintaining surfactant homeostasis and regulating inflammatory responses in the alveoli. Genetic variations in the SFTPA1 gene are associated with susceptibility to various respiratory diseases, including idiopathic pulmonary fibrosis (IPF) and respiratory distress syndrome.