分享产品介绍 评论(0)
物种
Human分子别名
Disintegrin and metalloproteinase domain-containing protein 22, Metalloproteinase-disintegrin ADAM22-3, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2, MDC2Accession
Q9P0K1表达序列
Protein sequence (Q9P0K1, Gly26-His528(Leu78Val), with C-His Tag) GQAGDASLMELEKRKENRFVERQSIVPLRLIYRSGGEDESRHDALDTRVRGDVGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIH
表达宿主
HEK293分子量
Predicted MW: 58.2 kDa Observed MW: 40 kDa纯度
＞90% by SDS-PAGE内毒素含量
<1EU/μg标记
Unconjugated性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
ADAM22 is a member of the ADAM (A Disintegrin And Metalloprotease) family of transmembrane proteins. Unlike many family members, it lacks proteolytic activity and functions primarily as a scaffold protein within the central nervous system. Its key role is to anchor the protein complex at the synapse that includes postsynaptic receptors and signaling molecules. By interacting with specific partners like LGI1 and PSD-95, ADAM22 is crucial for organizing the synaptic architecture at excitatory synapses, thereby facilitating proper neuronal communication. Mutations in genes encoding ADAM22 or its binding partners are linked to severe epileptic disorders.
电泳
2μg（R: reducing conditions）
评论(0)