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Human SFTPA2 Protein, His Tag

Pulmonary surfactant-associated protein A2,PSP-A,PSPA,SP-A,SP-A2,35 kDa pulmonary surfactant-associated protein,Alveolar proteinosis protein,Collectin-5,COLEC5,PSAP,SFTP1,SFTPA,SFTPA2B

Datasheet COA

价格￥2,000.00 （供应商现货： 3-5个工作日）

货号 S0A0195

数量

产品介绍

产品介绍评论(0)

产品规格

物种

Human
分子别名

Pulmonary surfactant-associated protein A2, PSP-A, PSPA, SP-A, SP-A2, 35 kDa pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-5, COLEC5, PSAP, SFTP1, SFTPA, SFTPA2B
Accession

Q8IWL1
表达序列

Protein sequence (Q8IWL1, Glu21-Phe248, with C-His Tag) EVKDVCVGSPGIPGTPGSHGLPGRDGRDGVKGDPGPPGPMGPPGETPCPPGNNGLPGAPGVPGERGEKGEAGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF
表达宿主

HEK293
分子量

Predicted MW: 25.8 kDa Observed MW: 33-40 kDa
纯度

＞95% by SDS-PAGE
内毒素含量

<1EU/μg
标记

Unconjugated
性状

Lyophilized Powder
缓冲体系

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
溶解方法

Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
储存条件

12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

背景介绍

Pulmonary Surfactant-Associated Protein A2 (SP-A2) is a critical component of pulmonary surfactant, a lipoprotein complex essential for reducing surface tension in the alveoli and preventing lung collapse. Encoded by the SFTPA2 gene, it is primarily synthesized and secreted by type II pneumocytes. SP-A2 is a collectin, characterized by its collagen-like domain and carbohydrate recognition domain, which enables its key role in innate host defense. It opsonizes pathogens, enhances phagocytosis by alveolar macrophages, and modulates inflammatory responses. Genetic variants in SFTPA2 are associated with susceptibility to respiratory diseases, including pulmonary fibrosis, respiratory distress syndrome, and increased risk of severe lung infections.