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Human NNMT Protein, His Tag

Nicotinamide N-methyltransferase,NNMT

价格 ￥2,500.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A0194
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Nicotinamide N-methyltransferase, NNMT

  • Accession

    P40261

  • 表达序列

    Protein sequence (P40261, Met1-Leu264, with C-His Tag) MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL

  • 表达宿主

    E.coli

  • 分子量

    Predicted MW: 31.3 kDa Observed MW: 30 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Nicotinamide N-methyltransferase (NNMT) is a cytoplasmic enzyme that catalyzes the methylation of nicotinamide (vitamin B3) using S-adenosyl methionine (SAM) as the methyl donor, producing S-adenosylhomocysteine (SAH) and 1-methylnicotinamide (MNA). Its overexpression is implicated in various cancers, metabolic disorders, and aging, as it consumes SAM and influences global epigenetic patterns by altering the SAM:SAH ratio. NNMT is now recognized as a key metabolic enzyme with potential as a therapeutic target for cancer and obesity.

  • 电泳

    • 2μg（R: reducing conditions）

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