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物种
Human分子别名
Oncostatin-M-specific receptor subunit beta, Interleukin-31 receptor subunit beta (IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB), OSMRBAccession
Q99650表达序列
Protein sequence (Q99650, Glu28-Ser739, with C-His Tag) ERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDDAKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQDSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRNNFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSGQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAGEGPSATFTKVTTPDEHSS
表达宿主
HEK293分子量
Predicted MW: 82.7 kDa Observed MW: 120-140 kDa纯度
＞95% by SDS-PAGE内毒素含量
<1EU/μg标记
Unconjugated性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
Oncostatin M-specific receptor subunit beta (OSMRβ) is a crucial signaling component for cytokines Oncostatin M (OSM) and interleukin-31 (IL-31). It does not function alone but forms complexes with other subunits: with glycoprotein 130 (gp130) for OSM signaling, and with the IL-31 receptor alpha for IL-31 signaling. This dual partnership allows OSMRβ to mediate a diverse range of biological processes, including inflammation, cell proliferation, differentiation, and apoptosis. Its signaling is notably implicated in the pathogenesis of various cancers, promoting tumor growth and metastasis. Furthermore, through its role in the IL-31 receptor, OSMRβ is a primary driver of pruritus (itch) in inflammatory skin conditions like atopic dermatitis, making it a significant therapeutic target.
电泳
2μg（R: reducing conditions）
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