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Human IGFBP-2 Protein, His Tag

Insulin-like growth factor-binding protein 2,IBP-2,IGF-binding protein 2,IGFBP-2,BP2,IBP2

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A0184
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Insulin-like growth factor-binding protein 2, IBP-2, IGF-binding protein 2, IGFBP-2, BP2, IBP2

  • Accession

    P18065

  • 表达序列

    Protein sequence (P18065, Ala36-Gln325, with C-His Tag) AEVLFRCPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQEARGVHTQRMQ

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 33.1 kDa Observed MW: 33 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Insulin-like growth factor-binding protein 2 (IGFBP2) is a member of the IGFBP family, which regulates the bioavailability and activity of insulin-like growth factors (IGF-I and IGF-II). Primarily secreted by the liver, IGFBP2 modulates cell proliferation, differentiation, and metabolism by binding IGFs with high affinity, preventing their interaction with IGF receptors. Beyond its IGF-dependent roles, IGFBP2 exhibits IGF-independent functions, influencing processes like apoptosis, angiogenesis, and tumor progression. Elevated IGFBP2 levels are associated with various cancers, including glioblastoma and prostate cancer, where it may promote invasiveness. Conversely, IGFBP2 also plays a role in metabolic disorders, such as obesity and diabetes, highlighting its diverse physiological and pathological significance.

  • 生物活性

    • Immobilized Human IGFBP-2 Protein, His Tag at 2 μg/mL (100 μL/well) can bind Human IGF-2 Protein, hFc tag (Cat. No. S0A4045) with EC50 of 3.2-3.6 ng/ml.

  • 电泳

    • 2μg（R: reducing conditions）

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