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物种
Human分子别名
Transmembrane protein PVRIG, CD112 receptor (CD112R), Poliovirus receptor-related immunoglobulin domain-containing protein, PVRIG, C7orf15Accession
Q6DKI7表达序列
Protein sequence (Q6DKI7, Thr41-Asp171, with C-hFc tag) TPEVWVQVRMEATELSSFTIRCGFLGSGSISLVTVSWGGPNGAGGTTLAVLHPERGIRQWAPARQARWETQSSISLILEGSGASSPCANTTFCCKFASFPEGSWEACGSLPPSSDPGLSAPPTPAPILRAD
表达宿主
HEK293分子量
Predicted MW: 39.7 kDa Observed MW: 54 kDa纯度
＞95% by SDS-PAGE内毒素含量
<1EU/μg标记
Unconjugated标签
with C-hFc tag性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose.
溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
PVRIG (also known as CD112R) is an immune checkpoint protein belonging to the DNAM-1/TIGIT/CD96 family. It interacts with its ligand, PVRL2 (CD112), which is expressed on antigen-presenting cells and tumor cells. PVRIG functions as a co-inhibitory receptor, primarily expressed on T cells and NK cells, and plays a critical role in modulating immune responses. By binding to PVRL2, PVRIG suppresses T-cell and NK-cell activation, contributing to immune evasion in cancers.
生物活性
Immobilized Human PVRIG Protein, hFc Tag at 2 μg/mL (100 μL/well) can bind Recombinant Human Nectin-2/PVRL2/CD112 Protein with EC50 of 9-45 ng/ml.
电泳
2μg（R: reducing conditions）
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