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Human FIS1 Protein, His tag

Mitochondrial fission 1 protein,FIS1 homolog (hFis1),Tetratricopeptide repeat protein 11 (TPR repeat protein 11),TTC11

价格 ￥360.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A0178
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Mitochondrial fission 1 protein, FIS1 homolog (hFis1), Tetratricopeptide repeat protein 11 (TPR repeat protein 11), TTC11

  • Accession

    Q9Y3D6

  • 表达序列

    Protein sequence (Q9Y3D6, Met1-Gly122, with C-His tag) MEAVLNELVSVEDLLKFEKKFQSEKAAGSVSKSTQFEYAWCLVRSKYNDDIRKGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDG

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 15.9 kDa Observed MW: 16 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 标签

    with C-His tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Mitochondrial fission 1 protein (Fis1) is a key regulator in mitochondrial fission, a process critical for maintaining mitochondrial dynamics and cellular homeostasis. Localized to the outer mitochondrial membrane, Fis1 recruits cytosolic dynamin-related proteins (e.g., Drp1) to drive mitochondrial fragmentation. Dysregulation of Fis1-mediated fission is linked to various cellular stress responses, apoptosis, and diseases such as neurodegenerative disorders and cancer. Research focuses on its interaction networks, post-translational modifications, and roles in mitochondrial quality control, shedding light on mechanisms underlying mitochondrial dysfunction and potential therapeutic targets.

  • 电泳

    • 2μg（R: reducing conditions）

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