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Human PAR1 Protein, His tag

Proteinase-activated receptor 1,PAR-1,Coagulation factor II receptor,Thrombin receptor,F2R,CF2R,PAR1,TR

价格 ￥1,400.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A0177
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Proteinase-activated receptor 1, PAR-1, Coagulation factor II receptor, Thrombin receptor, F2R, CF2R, PAR1, TR

  • Accession

    P25116

  • 表达序列

    Protein sequence (P25116, Ser42-Thr102, with C-His tag) SFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLT

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 8.8 kDa Observed MW: 15-26 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 标签

    with C-His tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Protease-activated receptor 1 (PAR1), also known as thrombin receptor, is a member of the G-protein-coupled receptor (GPCR) family and a critical mediator of cellular responses to proteolytic enzymes, particularly thrombin. Activated by proteolytic cleavage at its N-terminal domain, PAR1 initiates signaling cascades via G proteins (e.g., Gαq/11, Gα12/13), regulating processes like platelet aggregation, vascular smooth muscle contraction, inflammation, and wound healing. Dysregulated PAR1 signaling is implicated in thrombosis, atherosclerosis, cancer cell migration, and fibrotic diseases.

  • 电泳

    • 2μg（R: reducing conditions）

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