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Human PRDM1/Blimp1 Protein, His tag

PR domain zinc finger protein 1,BLIMP-1,Beta-interferon gene positive regulatory domain I-binding factor,PR domain-containing protein 1,Positive regulatory domain I-binding factor 1 (PRDI-BF1,PRDI-binding factor 1),BLIMP1

Datasheet COA

价格￥2,600.00 （ 1-2周）

货号 S0A0175

数量

产品介绍

产品介绍评论(0)

产品规格

物种

Human
分子别名

PR domain zinc finger protein 1, BLIMP-1, Beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, Positive regulatory domain I-binding factor 1 (PRDI-BF1; PRDI-binding factor 1), BLIMP1
Accession

O75626
表达序列

Protein sequence (O75626, Lys38-Gln223, with C-His tag) KMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQ
表达宿主

E.coli
分子量

Predicted MW: 23.5 kDa Observed MW: 25 kDa
纯度

＞95% by SDS-PAGE
内毒素含量

<1EU/μg
标记

Unconjugated
标签

with C-His tag
性状

Liquid
缓冲体系

Supplied as a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 5% glycerol.
储存条件

12 months from date of receipt, -20℃ as supplied.

背景介绍

PRDM1 (PR domain zinc finger protein 1) is a transcription factor critical for cell fate determination and terminal differentiation. It plays a pivotal role in B cell development, driving mature B cells into antibody-secreting plasma cells while repressing B cell identity genes. Beyond immunity, PRDM1 regulates differentiation in other lineages, such as T cells and epithelial cells, and acts as a tumor suppressor in multiple cancers by inhibiting cell proliferation and inducing apoptosis. Dysregulation of PRDM1 is linked to lymphoid malignancies (e.g., multiple myeloma, diffuse large B-cell lymphoma) and solid tumors.