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产品中心 药物靶点和Fc受体 小分子药物靶点蛋白

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Human BRD4 Protein, His tag

Bromodomain-containing protein 4,Protein HUNK1,HUNK1

价格 ￥500.00 （ 1-2周）
货号 S0A0171
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Bromodomain-containing protein 4, Protein HUNK1, HUNK1

  • Accession

    O60885

  • 表达序列

    Protein sequence (O60885, Ser42-Glu168, with N-His tag) STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE

  • 表达宿主

    E.coli

  • 分子量

    Predicted MW: 16.9 kDa Observed MW: 15 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    with N-His tag

  • 性状

    Liquid

  • 缓冲体系

    Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl (pH7.5), 300 mM NaCl, 5% glycerol.

  • 储存条件

    12 months from date of receipt, -20℃ as supplied.

背景介绍

  • Bromodomain - containing protein 4 (BRD4) is a pivotal protein in epigenetic regulation. As a member of the BET (bromodomain and extra - terminal domain) family, it binds to acetylated lysine residues on histone tails via its bromodomains. This binding enables BRD4 to recruit transcriptional co - activators, such as the positive transcription elongation factor b (P - TEFb), and facilitate the transition from transcription initiation to elongation. In normal cells, BRD4 is involved in cell cycle progression, differentiation, and development. However, in cancer, aberrant BRD4 function is frequently observed. It drives the over - expression of oncogenes, fueling tumor cell growth, proliferation, and survival.

  • 电泳

    • 2μg（R: reducing conditions）

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